Enforcing solution phase nanoscopic aggregation in a palindromic tripeptide.
نویسندگان
چکیده
C-terminal dimerization of a tripeptide palindrome afforded fibrillation in solution through an assembly probably driven by hydrogen bonding and hydrophobic contributions; such an approach provides an expeditious entry into fabrication of fibrillating peptides from non-fibrillating peptide sequences.
منابع مشابه
SOLUTION-SET INVARIANT MATRICES AND VECTORS IN FUZZY RELATION INEQUALITIES BASED ON MAX-AGGREGATION FUNCTION COMPOSITION
Fuzzy relation inequalities based on max-F composition are discussed, where F is a binary aggregation on [0,1]. For a fixed fuzzy relation inequalities system $ A circ^{F}textbf{x}leqtextbf{b}$, we characterize all matrices $ A^{'} $ For which the solution set of the system $ A^{' } circ^{F}textbf{x}leqtextbf{b}$ is the same as the original solution set. Similarly, for a fixed matrix $ A $, the...
متن کاملTripeptide arginyl-glycyl-aspartic acid (RGD) for delivery of Cyclophosphamide anticancer drug: A computational approach
Density functional theory (DFT) calculations were performed on tripeptide arginyl-glycyl-aspartic acid (RGD) as an efficient drug carrier to deliver the commercially famous cyclophosphamide (CP) anticancer drug within ethanol solution. The most negative binding energy (-5.22 kcal/mol) was measured for the CP-RGD-7 created through the H-bond interaction between the P=O (phosphoryl) oxygen atom o...
متن کاملKinetic precipitation of solution-phase polyoxomolybdate followed by transmission electron microscopy: a window to solution-phase nanostructure.
This study aimed to elucidate the structural nature of the polydisperse, nanoscopic components in the solution and the solid states of partially reduced polyoxomolybdate derived from the [Mo132] keplerate, [(Mo)Mo5]12-[Mo2 acetate]30. Designer tripodal hexamine-tris-crown ethers and nanoscopic molybdate coprecipitated from aqueous solution. These microcrystalline solids distributed particle rad...
متن کاملDissipative Particle Dynamics simulation hydrated Nafion EW 1200 as fuel cell membrane in nanoscopic scale
The microphase separation of hydrated perfluorinated sulfonic acid membrane Nafion was investigated using Dissipative Particle Dynamics (DPD). The nafion as a polymer was modelled by connecting coarse grained beads which corresponds to the hydrophobic backbone of polytetrafluoroethylene and perfluorinated side chains terminated by hydrophilic end particles of sulfonic acid groups [1, 2]. Each f...
متن کاملThermodynamic Investigation of Tripeptide Tyr-Aaa-Gly in Gas Phase in Different Solvents
Tripeptide Tyr-Aaa-Gly (1a, 2b) is methionine-enkephalin analogues [Aaa = (R,S)-(1adamantyl)glycine]. The unique structure of adamantane is reflected in its highly unusual physical and chemical properties, which can have many applications including drug design and drug delivery. In this research, Quantum-mechanical calculations were performed at the HF/6-31G, HF/6-31G*, B3LYP/6-31G, B3LYP/6-31+...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Chemical communications
دوره 20 شماره
صفحات -
تاریخ انتشار 2005